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    • 专利摘要:
    The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium at least: a) a cosmetic agent consisting of galactomannans with molar masses of between 5 and 630 kDa, preferably between 5 and 120 kDa, more preferably between 8 and 80 kDa, and crosslinked sulfated galactans with molar masses of between 7 and 3000 kDa, preferably between 7 and 1100 kDa, more preferably between 8 and 200 kDa, and b) a prebiotic and a probiotic.
    公开号:FR3075622A1
    申请号:FR1763139
    申请日:2017-12-22
    公开日:2019-06-28
    发明作者:Marc Dumas；David Notte；Francoise Pellicier
    申请人:LVMH Recherche GIE；
    IPC主号:
    专利说明:

    FIELD OF THE INVENTION
    The present invention relates to a cosmetic composition comprising a cosmetic agent constituted by galactomannans and crosslinked sulphated galactanes, and at least one prebiotic and one probiotic, and its use in particular for maintaining the balance of the skin microbiota and promoting and / or improving the resistance make-up.
    STATE OF THE ART
    The skin, the largest human organ, is colonized by billions of microorganisms (bacteria, yeasts, fungi, viruses ...) collectively called "microbiota" or "microflora". The term "skin microbiome" designates all of these microorganisms, their genome and their interactions with their environment.
    The number of bacteria present on the skin can reach millions per cm2.
    Human skin flora can be subdivided into two groups:
    The transient flora composed of mostly harmless fungi, viruses and bacteria, known as saprophytes, which feed on decaying organic matter from the environment. This flora is not permanent, it varies during the day, depending on the activities carried out and variations in the surrounding conditions and the exposure of individuals to these conditions. The most common transient species are Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus species;
    The resident flora is made up of commensal germs, that is to say living thanks to their host without causing damage to it. The composition of this flora is fixed, and after disturbances, its same components re-form spontaneously. These microorganisms (Gram positive, Gram negative bacteria ...) inhabit the epidermis and are mainly found in the upper layers of the stratum corneum as well as in the ducts of the sweat glands and pilosebaceous follicles and the epidermal appendages that are the nails. and the hair.
    These microorganisms are essential for life. In addition to their role in the appearance of body odors, they are indeed closely linked to the maintenance of a good state of health of the skin. Resident and transient microbes do not cause disease or malfunction under normal conditions, that is, when proper hygiene is ensured and when the resident flora, immune responses and barrier function of the skin are intact. The skin microbiota is thus able to play a barrier role and protect its host.
    In parallel, the epidermis generates lipids and antimicrobial peptides, such as β-defensins, receptors dedicated to the recognition of pathogens which, all together form "innate cutaneous immunity".
    By developing and multiplying, resident bacteria also produce toxic metabolites, bacteriocins, and serine proteases such as those of Staphylococcus epidermidis, which inhibit the growth of other microorganisms and prevent the formation of their biofilm. by which they adhere to the skin. .
    The commensal flora stimulates the skin barrier and innate immunity, thus allowing the maintenance of healthy and resistant skin. The balance of the skin's microbiota, as well as the expression of the ecological conditions of the skin environment (temperature, pH, salinity, hormonal contents, lipid and protein content, water and oxygen, UV exposure) are also essential. to this maintenance.
    In addition to intrinsic factors such as age, sex, genetic makeup and immune reactivity, extrinsic factors such as climate (temperature, ambient humidity, UV), drug treatments, the use of cosmetic hygiene products , skincare or make-up can have a significant impact on the composition of skin microbial communities.
    The composition of the skin microbiota has also been shown to be influenced by the ability of the skin to retain the water it contains and the production of sebum. The level of sebum is negatively correlated with the 3 diversity indices from 16S taxonomic data (order, family, genus and species) and the same trend was observed for an insensitive loss of water (reflecting the quality of the skin barrier) .
    These studies presented at the ASCB Congress in San Francisco in December 2016 by C Heusèle et al. and entitled ‘Microbiota disversity on healthy women’s face in relaton to skin biophysical characteristics’, show a correlation between sebum production and the barrier function of the skin with the composition and diversity of the microbiota.
    The variability of the human skin microbiota can then lead to an alteration of its structure (dysbiosis) and have consequences on health by causing the occurrence of skin dysfunctions or contributing to the development of pathologies via colonization and proliferation of the resident flora and / or transient. For example, there is a decrease in microbial diversity in certain pathologies such as atopic dermatitis (Flores G et al. J Drugs Dermatol 2014: 13 (11): 1365-72) and psoriasis (Alekseyenko A et al., Microbiome 2013: 1 (131): 2-17) The application in particular of makeup compositions, such as foundations, can thus disturb the balance of the skin microbiota, in particular by disturbing the bacterial diversity. The invisible make-up film applied to the skin can also temporarily generate a change in the hydrolipidic balance of the skin and scaling, factors which can upset the balance of the skin microbiota.
    The invisible make-up film applied to the skin can also temporarily generate a hypoxia condition capable of modifying the skin microbiota, in particular aerobic microorganisms which live on the surface of the seed coat where the oxygen content is highest. It has indeed been demonstrated that an application of foundation significantly impacted bacterial diversity (StaudingerT et al. J Appl. Microbiol 2011: 110 (6): 1381-9.
    The lipid film formed by an excessive production of sebum can also temporarily generate a hypoxia condition capable of modifying the skin microbiota, in particular aerobic microorganisms which live on the surface of the seed coat where the oxygen content is the highest.
    But hypoxia is also capable of altering the skin tissue itself on several levels: by reducing the formation of desmoglein-1, a protein constituting the cohesion links between cells and therefore of the resistance of the epidermis (Straseski J et al. Wound Repair Regen. 2009; 17 (4): 606-616), also by reducing the formation of aquaporin 3, a protein allowing the supply of water into the epidermis to hydrate the skin (Straseski J et al. Wound Repair Regen. 2009; 17 (4): 606-616), by stimulating the production of reactive oxygen molecules (ROS) which alter the constituents and cells of the skin (Nys K et al. Free Radie Biol Med. 2012; 52 (6): 1111-20) by inhibiting the formation of differentiating keratins such as keratin 10 (Straseski J et al. Wound Repair Regen. 2009; 17 (4): 606-616), and / or by increasing the presence of Matrix Metallo proteases or MMPs (Xia YP et al. J. Invest. Dermatol. 2001; 116: 50-56) which degrade the constituents of the skin like collagen which can impact the density of the skin and its firmness and consequently the opening of the pores and the formation of wrinkles and fine lines.
    It is therefore understandable, in particular for compositions for making up keratin materials and in particular for the skin, or compositions for oily skin or with a tendency to oily, to have ingredients capable of preserving the cutaneous ecosystem from the consequences of the hypoxia by ensuring at least one of the following protective actions: by preserving the microbiota and its diversity by providing it with the skin conditions that allow it, such as strengthening the skin barrier and controlling sebum production, by strengthening the cohesion of the epidermis to strengthen the resistance of the skin, by stimulating the formation of the skin barrier to maintain sufficient hydration in the skin, by detoxifying the skin of reactive oxygen species, by inhibiting the formation of MMPs, and / or by stimulating the formation of the Hypoxia inducing factor or HIF which ensures protection of the skin cells from hypoxia.
    There therefore remains the need to develop new cosmetic compositions for making up keratin materials, in particular for the skin, capable in particular of preserving the diversity of the microbiota, of controlling its development and of improving the quality of the keratin materials (skin, mucous membranes, dander) and in particular the skin, the relief and the grain of its surface which constitutes an ecological niche for these microorganisms, in particular to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular the microbial diversity, of strengthen the skin barrier, improve the resistance of the skin to stress, in particular prevent and / or limit the skin consequences of a hypoxic environment, reduce skin inflammation, promote flaking and / or epidermal renewal, decrease the loss of firmness involved in sagging pores and the formation of wrinkles and fine lines, to improve the uniformity of the complexion, and / or to promote and / or improve the hold of the make-up and the homogeneity of its distribution on the surface of the skin.
    The Applicant has demonstrated that the combination of a cosmetic agent constituted by galactomannans and crosslinked sulphated galactans, a prebiotic and a probiotic, makes it possible to meet this need. In particular, the Applicant has been able to show that a composition comprising a cosmetic agent consisting of galactomannans obtained from Caesalpinia spinosa of molar masses between 1 and 150kDa and of crosslinked sulfated galactans obtained from Kappaphycus alvarezii of molar masses 1 and 150kDa, and a pre- / pro-biotic complex comprising an alpha-gluco-oligosaccharide, a Polymnia Sonchifolia root extract rich in fructo-oligosaccharide, a lysate of Lactobacillus bacteria and a maltodextrin, made it possible to strengthen the formation of skin barrier, to improve the performance of the skin barrier, to promote the proper development of the epidermis and its resistance, to maintain the integrity of the protein structures of the skin involved in its maintenance, in the astringent effect on the pores and filling in the reliefs of the skin, activating the ability of the skin to resist a situation of hypoxia (lack of oxygen), to increase the control exerted by the skin on the microbiota, to ensure the energy homeostasis of the skin, to improve and / or reinforce the resistance of the skin to stress, and to decrease the 'inflammation.
    STATEMENT OF THE INVENTION
    A first object of the invention relates to a cosmetic composition comprising, in a physiologically acceptable medium at least: a) a cosmetic agent constituted by galactomannans of molar masses of between 5 and 630kDa, preferably between 5 and 120kDa, more preferably between 8 and 80kDa, and crosslinked sulfated galactans with molar masses of between 7 and 3000kDa, preferably between 7 and 1100kDa, more preferably between 8 and 200kDa, and b) a prebiotic and a probiotic. The invention also relates to a cosmetic method for caring for and / or making up keratin materials, in particular the skin, lips and / or eyes, comprising at least the application to said keratin materials of a cosmetic composition of care and / or makeup, in particular a makeup composition for the complexion, the lips or the eyes, preferably for the complexion.
    The cosmetic process is in particular intended to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its hydrolipidic film, improve the integrity and the resistance of the skin to stresses. , in particular to favor its adaptive capacities to the conditions of hypoxia and / or to limit the cutaneous consequences of a hypoxic environment, to favor the desquamation and / or the epidermal renewal, to decrease the loss of firmness, to decrease the loosening of the pores, to reduce the irregularities surface, improve the uniformity of the complexion, promote the energy homeostasis of the skin, and / or promote and / or improve the hold of the make-up and the uniformity of its deposition. The invention also relates to the non-therapeutic cosmetic use of at least one cosmetic agent consisting of galactomannans of molar masses of between 5 and 630kDa and crosslinked sulfated galactanes of molar masses of between 7 and 3000kDa, a prebiotic and a probiotic fraction. as defined according to the invention, as an association intended to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its hydrolipidic film, improve the integrity and the resistance of the skin to stress, in particular to favor its adaptive capacities to the conditions of hypoxia and / or to limit the cutaneous consequences of a hypoxic environment, to favor the desquamation and / or the epidermal renewal, to decrease the loss of firmness, to decrease the slackening of pores, decrease surface irregularities, improve homo fairness of the complexion, promote energetic homeostasis of the skin, and / or promote and / or improve the hold of the make-up and the uniformity of its deposition.
    DEFINITIONS
    By "keratin materials" is meant according to the invention the skin, the mucous membranes (in particular the lips), and the integuments. According to a particular embodiment, the composition is intended for topical application to the skin, the lips or the integuments, preferably the skin.
    By 'skin' is meant in particular the skin of the face and / or the neck, in particular the skin of the face, including the more specific areas of the eyelids (falling into the category of eye makeup products) and of the contour of the 'eye.
    By ‘cutaneous microbiota’ or ‘microflora’ is meant the microorganisms (bacteria, yeasts, fungi, viruses ...) present on the surface of keratin materials and in particular the skin.
    The term "skin microbiome" designates all of these microorganisms, their genome and their interactions with their environment.
    The term “skin ecosystem”, otherwise known as “skin biosphere”, is understood to mean, according to the invention, the skin microbiota and its host, the skin.
    By "imbalance of the skin microbiota" is meant in particular an imbalance in the composition and / or diversity of the skin microbiota.
    By “maintaining the skin ecosystem and / or maintaining the balance of the skin microbiota, in particular microbial diversity”, is meant according to the invention the capacity of the active agents or of a composition containing them to preserve or maintain the natural balance of the skin ecosystem, including in conditions of disturbances linked to internal and / or external factors. By "maintaining the balance of the skin microbiota" is meant in particular preserving or maintaining the composition and / or diversity of the microbiota, and controlling its development.
    By 'uniformity of complexion' is understood in particular to mean a luminous, homogeneous complexion, we also speak of radiance of the complexion, as opposed to 'alteration of complexion' which denotes in particular a dull, inhomogeneous, blurred complexion having surface irregularities and / or colored. In the case of oily skin, the change in complexion includes in particular a shiny complexion and a perception of discomfort and manifestations felt such as skin imperfections or aesthetic disorders.
    By “surface irregularities” otherwise called “skin imperfections”, is understood in particular according to the invention to relief irregularities (ex: pores, dander, fine lines and wrinkles, an imperfect skin texture) and / or irregularities of color. For the lips, these relief irregularities may include chapping or crevices.
    By “preventing and / or limiting the cutaneous consequences of a hypoxic environment, is meant in particular according to the invention maintaining the diversity of the microbiota, and / or preventing and / or improving the alterations of the skin linked to a transient condition of hypoxia , such as a decrease in cell cohesion, a decrease in water supply to the epidermis, an increase in the production of reactive oxygen molecules, an inhibition of the formation of differentiation keratins and / or a increased collagen breakdown.
    By “promoting the adaptive capacities of the skin to the conditions of hypoxia”, is meant according to the invention the effect of the cosmetic composition of the invention on the capacity of the skin to resist a situation of hypoxia (lack of (oxygen) by stimulating the expression of genes induced when the oxygen content of the skin is low and by allowing the metabolism to adapt to this new environment.
    By “promoting the energetic homeostasis of the skin” is meant according to the invention the capacity of the cosmetic composition to ensure the energetic homeostasis of the skin by contributing to the formation of ATP, a molecule for storing cellular energy. used to ensure the overall metabolism of skin cells.
    By "oily skin or with oily tendency", one understands in particular an oily skin characterized by an excessive presence on its surface of sebum, product of secretion of the sebaceous glands. This sebum production is ensured more particularly by the sebocytes through a process of cell differentiation and synthesis or accumulation of lipids called lipogenesis. We also speak of hyperseborrheic skin.
    Oily skin is often associated with a defect in flaking, an inflammatory site and / or an oxidation of lipids, which can cause a shiny complexion, an imperfect skin texture, a perception of discomfort and manifestations felt as skin imperfections or aesthetic disorders. ; such skin also exhibits poorer makeup performance during the day and particularly in the afternoon when the sebaceous production is at a maximum.
    In addition to its unsightly appearance, oily skin can be a breeding ground for the proliferation of microorganisms and thus participate in the occurrence of skin disorders (eg acne lesions). We will then speak of oily or hyperseborrheic skin with an acne tendency.
    By esth aesthetic skin disorders or non-pathological disorders associated with oily skin or with oily tendency ’, one understands in particular disorders due to a hyper-seborrhea, a defect of desquamation, a hypoxic environment and / or an imbalance of the microbiota. In particular, the associated aesthetic skin disorders are non-pathological disorders selected from a skin presenting an imbalance of the skin microbiota, a defect of desquamation, an oxidation of lipids, an alteration of the complexion, in particular a shiny complexion, a perception of discomfort, surface irregularities, in particular follicular orifices or enlarged pores, an imperfect skin texture, and / or a skin exhibiting less good makeup hold.
    DETAILED DESCRIPTION OF THE INVENTION The invention therefore relates in particular to a cosmetic composition comprising, in a physiologically acceptable medium at least: a) a cosmetic agent consisting of galactomannans with molar masses of between 5 and 630kDa, preferably between 5 and 120kDa, more preferably between 8 and 80kDa, and crosslinked sulfated galactans with molar masses of between 7 and 3000kDa, preferably between 7 and 1100kDa, more preferably between 8 and 200kDa, and b) a prebiotic and a probiotic.
    Galactomannans and crosslinked sulfated Galactanes The cosmetic agent within the meaning of the invention consists of biopolymers, that is to say polymers derived from plant materials, which are obtained by chemical synthesis.
    These biopolymers have a film-forming effect, that is to say an effect which can create a film on the surface of the skin not perceptible to the naked eye, in order to protect the skin from external aggressions such as pollution and allergens.
    Such biopolymers are described in particular in patent applications WO2017 / 19792 and WO2017 / 129780 of the Industrial Limousine Company of Biological Application. The cosmetic or dermocosmetic agent used according to the invention consists of: - galactomannans with molecular weights between 5 and 630kDa, and - crosslinked sulfated galactans with molar masses between 7 and 3000kDa.
    By "average molar mass" of a mixture of molecules is meant the average of the weight molar masses of each molecule in the mixture.
    By "crosslinked" is meant within the meaning of the invention a biopolymer in which a three-dimensional network has been formed by means of the formation of chemical or physical bonds between the molecules of the biopolymer.
    Preferably, the cosmetic or dermocosmetic agent consists of: - galactomannans with an average molar mass of between 5 and 120kDa, and crosslinked sulfated galactans with an average molar mass of between 7 and 1100kDa.
    Even more preferably, the cosmetic or dermocosmetic agent consists of: - galactomannans with an average molar mass of between 8 and 80kDa, and crosslinked sulfated galactans with an average molar mass of between 8 and 200kDa.
    The galactomannans can be obtained in particular from hydrolysis of galactomannans native to Tara (Caesalpinia spinosa), guar (Cyamopsis tetragonoloba), carob (Ceratonia siliqua), but also senna (Cass / a angustifolia), cassier (Cass / a fistula), cassia (Cass / a obtusifolia or Cass / a tora), carob (Gleditsia sinensis), honey locust (Gieditsia triacanthos), sophora (Sophora japonica) and / or fenugreek (Trigonella foenum-graecum ), preferably from Caesalpinia spinosa.
    The crosslinked sulfated galactans can be obtained by hydrolysis of sulfated galactans native to carrageenans (Kappaphycus alvarezii, Kappaphycus striatum, Eucheuma cottonii, Eucheuma spinosum, Chondrus crispus, Gigartina skottsbergii, Sacrothalia crsipataaria) fastigiata, Agar (Gelidium sesquipedalé) or algae (Polysiphonia lanosa or Codium fragile), preferably from Kappaphycus alvarezii. According to a particular embodiment of the invention, the cosmetic agent consists of galactomannans obtained by hydrolysis of galactomannans native to Tara (Caesalpinia spinosa), guar (Cyamopsis tetragonoloba), carob (Ceratonia siliqua), but also senna (Cassia angustifolia), cassia (Cassia fistula), cassia (Cassia obtusifolia or Cassia tora), chinese carob (Gleditsia sinensis), honey locust (Gieditsia triacanthos), sophora (Sophora japonica) and / or fenugreek (Trigonella foenum- graecum), preferably from Caesalpinia spinosa; and crosslinked sulfated galactans obtained by hydrolysis of sulfated galactans native to carrageenans (Kappaphycus alvarezii, Kappaphycus striatum, Eucheuma cottonii, Eucheuma spinosum, Chondrus crispus, Gigartina skottsbergii, Sacrothalia crsipataaria) , Agar (Gelidium sesquipedale) or algae (Polysiphonia lanosa or Codium fragile), preferably from Kappaphycus alvarezii.
    The crosslinked galactomannans and sulfated galactans are obtained according to the following steps:
    Solubilization of powder of native galactomannans or native sulfated galactans respectively in water,
    Gentle hydrolysis by chemical or enzymatic route; Separation of the soluble or insoluble phases, in order to eliminate the insoluble phase; Selection by membrane filtration (s) of galactomannans of defined molar mass.
    The crosslinked sulfated galactans are also crosslinked with a crosslinking agent, preferably a crosslinking agent of ionic nature.
    The galactomannans and crosslinked sulfated galactans thus obtained are mixed to constitute a cosmetic agent.
    According to a particular and preferred mode, the cosmetic agent a) according to the invention consists of 60 to 90% of galactomannans and 10 to 40% of crosslinked sulfated galactans.
    According to a particular and preferred embodiment, the cosmetic agent consists of galactomannans obtained from Caesalpinia spinosa of molar masses between 1 and 150kDa, and of crosslinked sulfated galactans obtained from Kappaphycus alvarezii of molar masses in particular between 1 and 150kDa .
    According to a particular embodiment of the invention, the cosmetic agent a) is present in the composition in a content ranging from 0.01% to 2% by weight of active material relative to the total weight of the composition, preferably 0.1 % to 0.1%, and more preferably still from 0.4% to 0.8% by weight of active material relative to the total weight of the composition.
    By "active ingredient" is meant the active compounds of the cosmetic agent to which the efficacy is attributed. We also speak of dry matter for plant extracts.
    Such biopolymers are described in patent applications WO2017 / 19792 and WO2017 / 129780 of the Industrial Limousine Company of Biological Application, in particular example 1 of application WO2017 / 129780. The use of these biopolymers improves the skin barrier effect by protecting the skin against the penetration of toxic molecules, such as pollutants, allergens, heavy metals. The film effect after application to the skin also improves the overall appearance of the face and promotes the retention of pigments and makeup.
    According to a particular and preferred mode, a product sold by the company SILAB under the trade name FILMEXEL®, of the INCI name 'CAESALPINIA SPINOSA EXTRACT and KAPPAPHYCUS ALVAREZII EXTRACT and WATER', will be used as cosmetic agent constituted by galactomannans and galactanes sulftates crosslinked. in the form of powder and composition CAESALPINIA SPINOSA EXTRACT 76%, KAPPAPHYCUS ALVAREZII EXTRACT 19%, and WATER 5% (95% active or dry matter).
    Prebiotic / probiotic complex (synbiotic)
    The term "prebiotic" means non-living food constituents which have the property of modulating the growth and activity of probiotic strains (lactobacilli, bifidobacteria ...) and other bacterial strains of the intestine beneficial to human health. Prebiotics are generally monosaccharides, disaccharides or oligosaccharides, which can be found naturally in fruits, vegetables, and honey and are extractable. Others are produced industrially by hydrolysis of polysaccharides (for example fructo-oligosides or oligofructoses, abbreviated as FOS for Fructo-oligosaccharides) or synthesized by subjecting disaccharides such as lactose to the action of enzymes such as lactases with transferase activities to produce trans-galacto-oligosaccharides (TOS) or by a chemical isomerization reaction which gives lactulose. Currently, trans-galactooligosaccharides (GOS) and inulin-type fructans are those whose prebiotic effects are recognized.
    The term “probiotic or derivative” is understood to mean living or inactivated microorganisms which, when ingested in sufficient quantity, exert positive health effects beyond the traditional nutritional effects.
    Probiotics can be bacteria or yeast.
    The probiotic or derivative can be chosen from a strain of one or more of the following: Lactobacillus, strains and derivatives of Clostridia, strains and derivatives of Bifidobacterium, strains and derivatives of Saccharomyces, strains and derivatives of Lactococcus, strains and derivatives of Pedicoccus, strains and derivatives of Enterococcus, strains and derivatives of Escherichia, strains and derivatives of Alcaligenes, strains and derivatives of Corynebacterium, strains and derivatives of Bacillus, and strains and derivatives of Propionibacterium.
    Mention may in particular be made of bacteria of the genera Lactobacillus and Bifidobacterium. The strains identified as probiotics apply mainly to the intestinal sphere, these include Lactobacillus acidophilus, L. casei, L. gasseri, L. paracasei, L. Rhamnosus and Bifidobacteria animal, B. breve, B. longum.
    As yeasts, there may be mentioned in particular Saccharomyces cerevisiae var. boulardii which is found naturally in lychee.
    By "synbiotics" is meant combinations of probiotics and prebiotics.
    According to a particular mode, the prebiotic is chosen from the group consisting of inulin and alpha-glucan oligosaccharide.
    According to a particular mode, the probiotic is chosen from the group consisting of lysates of probiotics. Preferably, the probiotic lysate is a lysate of the genus Bacillus.
    According to a particular and preferred embodiment, the cosmetic composition of the invention comprises, as prebiotic / probiotic complex Ecoskin® sold by the company SOLABIA, which is a mixture of alpha-glucan oligosaccharide, of sonchifolia root juice of polymnia, maltodextrin, and Lactobacillus sp bacteria, INCI name:
    ALPHA-GLUCAN OLIGOSACCHARIDE and POLYMNIA SONCHIFOLIA ROOT JUICE and MALTODEXTRIN and LACTOBACILLUS
    The composition of Ecoskin® is: ALPHA-GLUCAN OLIGOSACCHARIDE 70%, POLYMNIA SONCHIFOLIA ROOT JUICE 19%, MALTODEXTRIN 10%, LACTOBACILLUS 1% (corresponding to 90% of active ingredient). It is a pre / probiotic complex, spray dried on maltodextrin, made of: a-gluco-oligosaccharides (GOS) obtained by enzymatic synthesis from plant substrates (corn maltose, beet sucrose), 100% juice pure plants rich in β-fructooligosaccharides (FOS) obtained by cold pressing of tubers of Polymnia sonchifolia, and of a probiotic bacterium of Lactobacillus (L. casei, L. acidophilus), inactivated by tyndallization and lyophilized.
    The prebiotic portion comes from α-gluco-oligosaccharides (GOS) and β-fructooligosaccharides from the cold pressed extract of Polymnia sonchifolia tubers; these prebiotics stimulate the ecoflora of the skin.
    Probiotics are the inactivated Lactobacillus bacteria that stimulate the beta-defensins that are involved in the skin's defense system. The strains of Lactobacillus bacteria (Lactobacillus casei and Lactobacillus acidophilus) which are used in Ecoskin® are previously lyophilized and tyndallized, which means that their reproductive system is inactivated by heat preventing their development in the cosmetic preparations which contain them.
    According to a particular mode, the prebiotic / probiotic complex is present in the composition in a content ranging from 0.05% to 3% by weight of active material relative to the total weight of the composition, preferably from 0.1 to 1% by weight of active material relative to the total weight of the composition.
    According to a particular mode, the cosmetic composition can also comprise at least one hydrolyzate of beans of Theobroma cocoa L.
    Hydrolyzate of Theobroma cocoa L The hydrolyzate of Theobroma cocoa L. according to the invention is a peptide and osidic hydrolyzate of the beans of Theobroma cocoa L mainly comprising peptides and osides. The term "mainly peptides and osides" means an amount greater than 50%, preferably greater than 60%, preferably still greater than 70% and up to approximately 90% (weight / weight) of dry matter in peptides and in oses, preferably 90% of the weight of the dry matter.
    The term “peptide and osidic hydrolyzate” means a hydrolyzate comprising mainly or essentially peptides and oses (mono and oligosaccharides). The proteins and polysaccharides naturally present in the beans have been hydrolyzed into peptides, oligosaccharides and monosaccharides, advantageously the hydrolysis is an enzymatic hydrolysis.
    This hydrolyzate can be obtained as follows: a) ground beans of Theobroma cocoa L are dispersed in the aqueous phase; b) carrying out an enzymatic treatment of the aqueous dispersion obtained in step a); c) the enzymatic hydrolyzate is recovered by solid / liquid separation, d) the hydrolyzate is purified by ultrafiltration and nanofiltration, then optionally; e) lyophilization of the hydrolyzate obtained in step d) is carried out. The hydrolyzate used according to the invention is obtained from Theobroma cocoa L beans, as starting material, which can include either the bean alone or the bean and its husk, preferably the beans comprising the bean and its husk will be used. The non-lyophilized cocoa hydrolyzate used according to the invention comprises from 20 to 70% of peptides and from 5 to 40% of osides. The lyophilized cocoa hydrolyzate without drying support according to the invention comprises more than 90 percent of dry matter comprising from 20 to 70% of peptides and from 5 to 40% of osides.
    In another highly preferred embodiment according to the invention, the peptides and osides present in the hydrolyzate used according to the invention have a molecular weight of between 200 Da and 10 kDa.
    Thus, according to a particular and preferred embodiment, the hydrolyzate of Theobroma cocoa L beans is a peptide and osidic hydrolyzate of Theobroma cocoa L beans, comprising in particular peptides and osides having a molecular weight of between 200 Da and 10 kDa. The hydrolyzate thus obtained can then be further diluted in water or in any mixture of solvents containing water. Thus, the cocoa hydrolyzate according to the invention can advantageously be diluted in one or more physiologically acceptable solvents, such as water, glycerol, ethanol, propanediol, butylene glycol, dipropylene glycol, ethoxylated diglycols or propoxylated, cyclic polyols or any mixture of these solvents.
    To prepare the composition, the cocoa hydrolyzate according to the invention can be in liquid or lyophilized form. According to a particular mode, it is in a liquid form.
    According to a particular and preferred mode, the hydrolyzate of Theobroma cocoa L. will be used a product marketed by the company ASHLAN under the trade name BLUMILIGHT ™, of INCI name 'BUTYLENE GLYCOL and WATER and THEOBROMA CACAO (COCOA) SEED EXTRACT' of a liquid and composition BUTYLENE GLYCOL 55%, WATER 43.75%, THEOBROMA CACAO (COCOA) SEED EXTRACT 1.25% (1.25% of active matter or dry matter).
    According to a particular mode, the hydrolyzate of beans of Theobroma cacao L. is present in the composition in a content ranging from 0.0005 to 0.025% by weight of active material relative to the total weight of the composition, preferably from 0.001 to 0 , 01% by weight of active material relative to the total weight of the composition.
    galenic
    The compositions according to the invention are intended more particularly for topical application to keratin materials, in particular to the skin.
    The compositions of the invention comprise a cosmetically acceptable medium, that is to say compatible with the skin and the integuments. The compositions can have all cosmetic forms, and in particular can be in the form of creams, oil-in-water emulsions, or water-in-oil or multiple emulsions, solutions, suspensions, gels, milks, lotions, serums, sticks or else powders, and suitable for application to the skin, lips and / or integuments.
    According to a particular embodiment, the composition of the invention is intended for topical application to the skin, the lips or the eyes and is in the form of a care product and / or a make-up product for the skin. , lips and or eyes, in particular for the complexion.
    We will talk indifferently of skin make-up or make-up for the complexion.
    By "eye makeup" is meant in particular liners, or eyeshadows.
    According to a particular and preferred mode, the composition of the invention is in the form of a foundation, or of a foundation, preferably of a foundation.
    According to a particular and preferred embodiment, the composition of the invention is in the form of a foundation powder, a foundation, or a foundation, preferably a foundation.
    The cosmetic composition of the invention is advantageously in the form of an oil-in-water emulsion, a water-in-oil emulsion, a multiple emulsion, an aqueous gel.
    The composition is preferably in the form of an emulsion containing an aqueous phase and an oily phase.
    The aqueous phase generally represents from 1 to 99% by weight, relative to the total weight of said composition.
    The composition of the invention generally comprises, in addition to the aqueous phase, also an oily phase.
    An oily phase according to the invention can comprise hydrocarbon oils, silicone oils, fluorinated or not, and mixtures thereof. These oils can be volatile or non-volatile, vegetable, mineral or synthetic.
    Advantageously, use will be made of hydrocarbon oils.
    As volatile hydrocarbon oils, mention may in particular be made of branched C8-C16 alkanes, branched C8-C16 esters and mixtures thereof.
    As non-volatile hydrocarbon oils, mention may in particular be made of hydrocarbon oils, hydrocarbon oils of vegetable origin, synthetic ethers of C10-C40, synthetic esters of C10-C40, fatty alcohols of C12-C26, acids higher C12-C22 fats, and mixtures thereof.
    The oils may be present in the composition of the invention in a content ranging from 1 to 95% by weight relative to the total weight of the composition.
    The composition of the invention can also comprise any additive usually used in cosmetics such as UV filters, antioxidants, surfactants, gelling agents, fillers, coloring matters, preservatives, film-forming polymers, perfumes, agents cosmetic active ingredients, such as emollients, moisturizers, vitamins, anti-aging agents, lightening agents, and mixtures thereof.
    According to a particular embodiment of the invention, the cosmetic composition comprises at least one or more coloring matters.
    The dyestuffs can be chosen from dyestuffs which are water-soluble or not, liposoluble or not, organic or inorganic, materials with an optical effect, and mixtures thereof.
    For the purposes of the present invention, the term “coloring matter” is intended to mean a compound capable of producing a colored optical effect when it is formulated in a sufficient amount in an appropriate cosmetic medium.
    According to a particular embodiment, the dye (s) are chosen in particular from inorganic and / or organic pigments, composite pigments (based on inorganic and / or organic materials), dyes, nacres or pearlescent pigments, and mixtures thereof.
    The term “pigments” should be understood to mean white or colored, inorganic (mineral) or organic particles, insoluble in the liquid organic phase, intended to color and / or opacify the composition and / or the deposit produced with the composition.
    Among the mineral pigments, there may be mentioned, by way of example, titanium dioxide (rutile or anatase), optionally surface-treated; black, yellow, red and brown iron oxides; manganese violet; ultramarine blue chromium oxide hydrated chromium oxide and ferric blue.
    For compositions intended for the lips, mention may be made, by way of examples, of titanium dioxide; black, yellow, red and brown iron oxides and manganese violet.
    Among the organic pigments that may be mentioned, for example, the pigments D & C red No. 19; D & C red No. 9; D & C Red No. 22; D & C Red No. 21; D & C Red No. 28; D & C Yellow # 6; D & C orange n ° 4; D & C orange No. 5; D & C Red No. 27; D & C red No. 13; D & C Red # 7; D & C Red # 6; D & C Yellow No. 5; D & C Red n ° 36 ;; D & C Red No. 33; D & C orange No. 10; D & C yellow n ° 6; ; D & C Red No. 30; D & C red n ° 3; D & C Blue 1; carbon black and cochineal carmine lacquers.
    Among the water-soluble dyes, mention may be made of Yellow 5, Yellow 6, Blue 1, Green 5, Green 3, Green 6, Orange 4, Red 4, Red 21, Red 22, Red 27, Red 28, Red 33, Red 40, cochineal carmine (Cl 15850, Cl 75470).
    The liposoluble dyes are for example Sudan red, D & C Red 17, D & C Green 6, beta-carotene, soybean oil, Sudan brown, D & C Yellow 11, D & C Violet 2, D & C Orange 5, quinoline yellow, annatto.
    The nacres or nacreous pigments can be chosen in particular from white nacreous pigments, such as mica coated with titanium oxide, bismuth oxychloride; and colored pearlescent pigments, such as titanium mica with iron oxides, titanium mica with ferric blue or chromium oxide, titanium mica with an organic pigment of the aforementioned type, as well as pigments based on bismuth oxychloride. We can cite the ranges of pearls of commercial reference Reflecks®, Ronastar®, Timiron® and Syncristal®.
    In particular, the dye (s) are present in the composition in a content ranging from 2% to 30% by weight, preferably from 4% to 15% by weight relative to the total weight of the composition.
    According to a particular embodiment, the composition of the invention comprises pigments, in particular mineral pigments in a content ranging from 5 to 25%, in particular from 10 to 20% by weight relative to the total weight of the composition.
    The fillers are chosen in particular from silicas, micas, of natural or synthetic origin, kaolin, oxides of zinc and titanium; calcium carbonate, carbonate and magnesium hydrocarbonate; zinc, magnesium or lithium stearate, zinc laurate, magnesium myristate; powders of synthetic polymers, such as polyethylene, polyesters, polyamides (for example nylon); powders of polyacrylic or polymethacrylic acids, powders of silicone resin; mineral powders such as spherical silica; spherical titanium dioxides; glass and ceramic beads; powders of organic materials of natural origin such as starches from corn, wheat, rice, crosslinked or not, and mixtures thereof.
    According to a particular embodiment, the composition of the invention comprises pigments, in particular mineral pigments in a content ranging from 5 to 25%, in particular from 10 to 20% by weight relative to the total weight of the composition.
    According to a particular embodiment of the invention, the cosmetic composition does not contain any other cosmetic active ingredients than those which are the subject of the invention.
    According to another particular mode of the invention, the composition also contains other cosmetic and / or dermatological active ingredients. Mention may in particular be made of the active agents intended to stimulate the biodiversity and / or the homeostasis of the cutaneous microbiota, the cell renewal, the regeneration or revitalization of the complexion (radiance), the reduction of sebum production, the protection against external aggression.
    Mention may in particular be made of the following active agents intended to stimulate: - biodiversity and homeostasis of the skin microbiota, as does the active ingredient Actibiome® (Water and seawater and glycerin and Laminaria digitata extract and Chlorella vulgaris extract and saccharide isomerate and phenoxyethanol and ethylhexylglycerin), by rebalancing the pH of the skin previously decreased by a period of stress; - cell renewal, with the help of "peeling" active agents alone or in combination and at acid pH:. chemically, such as Alpha Hydroxylated Acids AHA (glycolic, lactic, citric acid ...), Beta Hydroxylated Acids BHA (salicylic acid), Poly Hydroxylated Acids PHA (gluconolactone); . biologically, such as Exfolactive C EL PX® (Opuntia coccinellifera), DERMOCH DP® (Chlorella vulgaris), ALGOWHITE® (Ascophyllum nodosum). enzymatically, such as MELACLEAR® (Gluconic acid, Sutilains); - regeneration or revitalization of the complexion (radiance), using active ingredients:. straighteners like Retinol (vitamin A-like). lightening by action on melanogenesis (vitamin C derivative). energizers such as nutrients and / or antioxidants vitamin C and E like SEPIVITAL® (potassium ascorbyl tocopheryl phosphate) - the reduction of the production of sebum, using sebum-capturing agents (Clays) or sebo-active regulators such as Zinc gluconate (Mineralis GU / Zn) and avocado lipophyl extract (5 alpha avocuta), - protection against external aggressions: pollution, blue light, UV using chemical or mineral filters and / or reflective diffusing particles, and mixtures thereof. The invention also relates to a cosmetic method for caring for and / or making up keratin materials, in particular the skin, lips and / or eyes, comprising at least the application to said keratin materials of a cosmetic composition of care and / or makeup as defined according to the invention, in particular a makeup composition for the complexion, the lips or the eyes, preferably for the complexion.
    The cosmetic process is in particular intended to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its hydrolipidic film, improve the integrity and the resistance of the skin to stress, in particular to favor its adaptive capacities to the conditions of hypoxia and / or to limit the cutaneous consequences of a hypoxic environment, to favor the desquamation and / or the epidermal renewal, to decrease the loss of firmness, to decrease the sagging of the pores, to decrease surface irregularities, improve the uniformity of the complexion, promote the energetic homeostasis of the skin, and / or promote and / or improve the hold of the make-up and the uniformity of its deposition. The invention also relates to the non-therapeutic cosmetic use of at least one cosmetic agent consisting of galactomannans of molar masses of between 5 and 630kDa and crosslinked sulfated galactanes of molar masses of between 7 and 3000kDa, a prebiotic and a probiotic fraction. as defined according to the invention, as an association intended to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its hydrolipidic film, improve the integrity and the resistance of the skin to stress, in particular promoting its adaptive capacities to hypoxia conditions and / or limiting the cutaneous consequences of a hypoxic environment, favoring desquamation and / or epidermal renewal, reducing the loss of firmness, reducing sagging pores, decrease surface irregularities, improve h homogeneity of the complexion, promote energetic homeostasis of the skin, and / or promote and / or improve the hold of the make-up and the homogeneity of its deposition. The invention will be illustrated by the following nonlimiting examples. The percentages are expressed as a percentage by weight relative to the total weight of the composition unless otherwise indicated.
    EXAMPLES
    Example 1 Effect of the Combination of an Extract of Caesalpinia Spinosa with an Extract of Kappaphycus Alvarezii (Filmexel®) in Combination with Ecoskin® on Keratinocytes
    A study on the transcriptional effects of these active ingredients, used alone or in combination, was carried out using TLDA technology (TaqMan Low Density Array). Thanks to this technology, the modulation of the expression of genes coding for specific proteins is studied in response to a treatment of Normal Human Keratinocytes, which allows a mapping of the gene expression of the active ingredients alone or in combination.
    This approach allows, in particular, to highlight the beneficial effects of the active ingredients or their combination in the fields covered by the profile: formation of the epidermis and desquamation, extracellular matrix, detoxification and anti-oxidation, inflammation and innate immunity.
    Material and methods
    Cells used: Normal keratinocytes of human epidermis
    Culture medium: EpiLife® supplemented with HKGS (Human-Keratinocyte-Growth-Supplement)
    Skin origin of cells: abdominal sample, woman, 47 years old
    Study model: TLDA technology (TaqMan Low Density Array)
    Cell treatment with compounds: 24h
    Tested compounds: • ECOSKIN® (ALPHA-GLUCAN OLIGOSACCHARIDE and POLYMNIA SONCHIFOLIA ROOT JUICE and MALTODEXTRIN and LACTOBACILLUS) at 0.25% • FILMEXEL® (CAESALPINIA SPINOSA EXTRACT and KAPPAPHYCUS ALVAREZEL% 0.2% EXTRACT® 0.2%) at 0.25% Results
    Table 1 below shows the variations in activity for the genes studied.
    The experimental conditions used are as follows: - Each test is carried out in triplicate (3 not treated and 3 treated under the same conditions); - Fischer's F-test is first applied by comparing the two data matrices. When the value is greater than a = 0.05 then the variance of Student's t-test is 2, when the Fischer's F-test is less than a = 0.05, then the variance will be equal to 3. - The variations Transcriptional retained (significant) will be those that correspond to a Student's t test less than or equal to a (or p) = 0.05. In dark gray the stimulations (see below) the white background indicating the non-significant variations, that is to say those corresponding to a Student t test greater than alpha (or p) = 0.05.
    Table 1
    These data highlight, for the associations tested, a synergistic effect allowing: - to strengthen the formation of the skin barrier in particular the formation of corneocytes (cell envelope) by stimulating the transcriptional activity of the IVL and PI3 genes - to improve the performance of the skin barrier by stimulating the transcriptional activity of the CLDN1 and OCLN genes, involved in the formation of tight intercellular junctions which limit the passage of intercellular water (insensitive water loss) and maintain epidermal lipids on the skin surface , and by stimulating the transcriptional activity of the SLC27A4 gene involved in the transport of epidermal lipids - promoting the proper development of the epidermis and its resistance in particular by stimulating the transcriptional activity of the SOCS3, TGFBR1, KRT5 genes, - maintaining the integrity of the protein structures of the skin involved in its maintenance, in the astringent effect on the pores and the filling of the reliefs of the skin, by preventing the degradation of these protein structures by the activation of the genes of the protease inhibitors like SERPINB3, SERPINB7 and PI3 - to activate the ability of the skin to resist a situation of hypoxia (lack of oxygen) stimulating the transcriptional activity of the HIF1a gene induced when the content of
    oxygen in the skin is low and allows the metabolism to adapt to this new tissue environment, - to increase the control exerted by the skin on the microbiota by stimulating the transcriptional activity of the PI3 gene, a bactericidal antimicrobial peptide. - to ensure energy homeostasis of the skin by stimulating the transcriptional activity of the ATP2C1 gene which contributes to the formation of ATP, a cell energy storage molecule used to ensure the whole metabolism of skin cells. - improve and / or strengthen the resistance of the skin to stress by protecting it from toxins by stimulating the transcriptional activity of the GSTZ1 gene, which allows their elimination by coupling with the glutathione molecule, while limiting inflammation by stimulating the transcriptional activity of the PI3 gene.
    These results show that the cosmetic composition of the invention makes it possible to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its hydrolipidic film, improve the integrity and the resistance of the skin, promote its adaptive capacity to hypoxia conditions, strengthen the detoxification process and balance inflammation, reduce the loss of firmness, reduce sagging pores and the formation of skin relief imperfections (wrinkles and fine lines ), promote and / or improve the homogeneity of distribution of a make-up product, and provides the skin with the energy necessary for tired and dull skin and thus improve their radiance.
    Example 2 Cosmetic Formulations
    Cosmetic formulations are prepared according to conventional methods of formulations. The percentages are expressed as percentages by weight of ingredient (raw material) relative to the total weight of the composition.
    A moisturizing day cream for combination skin:
    GLYCEROL VEGETAL (Glycerin) 6.0% FILMEXEL® (Caesalpinia spinosa fruit extract and Kappaphycus alvarezii extract and water) 0.50% ECOSKIN® (Alpha-glucan oligosaccharide and Polymnia sonchifolia root juice and Maltodextrin and Lactobacillus) 0.50%
    RENOHYAL (Sodium Hyaluronate) 0.10%
    Isononyl isononanoate 10.0%
    Steareth-2 12.5% G lyceryl stearate 1.1%
    Stearyl alcohol 5.0%
    Butylene glycol 3.0%
    Glycerin 2.0%
    Preservative 0.5%
    Water, qs 100%
    A gel for combination skin:
    GLYCEROL VEGETAL (Glycerin) 6.0% ECOSKIN® (Alpha-glucan oligosaccharide and Polymnia sonchifolia root juice and Maltodextrin and Lactobacillus) 0.50% FILMEXEL® (Caesalpinia spinosa fruit extract and Kappaphycus alvarezii extract and water) 1.00%
    RENOHYAL (Sodium Hyaluronate) 0.1%
    Glycol 3.0%
    AMPS polymer 3.0%
    Mineral oil 2.0%
    Polyethylene glycol 1.5%
    Preservative 0.5%
    Fragrance concentrate 0.3%
    Water, Qs 100%
    An ECOSKIN® Foundation (Alpha-glucan oligosaccharide and Polymnia sonchifolia root juice and Maltodextrin and Lactobacillus) 0.50% FILMEXEL® (Caesalpinia spinosa fruit extract and Kappaphycus alvarezii extract and water) 0.50%
    IRON OXIDES AND TITANIUM DIOXIDE (Black Cl 77499, red Cl 77491, yellow Cl 77492, White Cl 77891) 18.0%
    Cyclopentasiloxane and cyclohexasiloxane 5.0%
    Cetyl dimethicone 1.0%
    Caprylic / capric triglycerides 2.2%
    Octyl stearate 1.4%
    Mineral oil 3.5%
    Beeswax 0.8%
    Polymethyl methacrylate 1.1%
    Perfume concentrate 0.1%
    Water, qs 100%
    A SPF BLUMILIGHT ™ Foundation (Butylene glycol and Water and Theobroma cacao (cocoa) seed extract) 0.10% FILMEXEL® (Caesalpinia spinosa fruit extract and Kappaphycus alvarezii extract and water) 0.50% ECOSKIN® (Alpha-glucan oligosaccharide and Polymnia sonchifolia root juice and Maltodextrin and Lactobacillus) 0.50% UV-TITANE M160 (Titanium dioxide, TiO2 (nano)) 2.0%
    ZINC OXIDE (Zinc oxide, Cl 77947) 3.0%
    IRON OXIDES AND TITANIUM DIOXIDE (Black Cl 77499, red Cl 77491, yellow Cl 77492, White Cl 77891) 16.0%
    Cyclopentasiloxane and cyclohexasiloxane 5.0%
    Cetyl dimethicone 1.0%
    Caprylic / capric triglycerides 2.2%
    Octyl stearate 1.4%
    Mineral oil 3.5%
    Beeswax 0.8%
    Polymethyl methacrylate 1.1%
    Perfume concentrate 0.1%
    Water, qs 100%
    权利要求:
    Claims (12)
    [1" id="c-fr-0001]
    1. Cosmetic composition comprising, in at least one physiologically acceptable medium: a) a cosmetic agent consisting of galactomannans with molar masses of between 5 and 630kDa, preferably between 5 and 120kDa, more preferably between 8 and 80kDa, and galactans crosslinked sulfates of molar masses between 7 and 3000kDa, preferably between 7 and 1100kDa, more preferably between 8 and 200kDa, and b) a prebiotic and a probiotic.
    [2" id="c-fr-0002]
    2. Cosmetic composition according to claim 1, characterized in that the cosmetic agent consists of galactomannans obtained by hydrolysis of galactomannans native to Tara (Caesalpinia spinosa), guar (Cyamopsis tetragonoloba), carob (Ceratonia siliqua), but also of senna (Cassia angustifolia), cassia (Cassia fistula), cassia (Cassia obtusifolia or Cassia tora), chinese carob (Gleditsia sinensis), honey locust (Gieditsia triacanthos), sophora (Sophora japonica) and / or fenugreek ( Trigonella foenum-graecum), preferably from Caesalpinia spinosa; and crosslinked sulfated galactans obtained by hydrolysis of sulfated galactans native to carrageenans (Kappaphycus alvarezii, Kappaphycus striatum, Eucheuma cottonii, Eucheuma spinosum, Chondrus crispus, Gigartina skottsbergii, Sacrothalia crsipataaria) , Agar (Gelidium sesquipedale) or algae (Polysiphonia lanosa or Codium fragile), preferably from Kappaphycus alvarezii.
    [3" id="c-fr-0003]
    3. Cosmetic composition according to claim 1 or 2, characterized in that the cosmetic agent a) consists of 60 to 90% of galactomannans and 10 to 40% of crosslinked sulfated galactans.
    [4" id="c-fr-0004]
    4. Cosmetic composition according to one of claims 1 to 3, characterized in that the cosmetic agent consists of galactomannans obtained from Caesalpinia spinosa of molar masses between 1 and 150kDa, and of crosslinked sulfated galactanes obtained from Kappaphycus alvarezii with molar masses in particular between 1 and 150kDa.
    [5" id="c-fr-0005]
    5. Cosmetic composition according to any one of claims 1 to 4, characterized in that the cosmetic agent a) is present in the composition in a content ranging from 0.01% to 2% by weight of active material relative to the weight total of the composition, preferably 0.1% to 0.1%, and more preferably from 0.4% to 0.8% by weight of active material relative to the total weight of the composition.
    [6" id="c-fr-0006]
    6. Cosmetic composition according to any one of claims 1 to 5, characterized in that it comprises at least, as a prebiotic, at least one alpha-gluco-oligosaccharide and advantageously also at least one fructo-oligosaccharide, and as a probiotic, at least one lysate of the genus Bacillus.
    [7" id="c-fr-0007]
    7. Cosmetic composition according to claim 6, in which the prebiotic and the probiotic are in the form of a pre- / pro-biotic complex comprising an alpha-gluco-oligosaccharide, a Polymnia Sonchifolia root extract rich in fructo-oligosaccharide. , a lactate of Lactobacillus bacteria and a maltodextrin.
    [8" id="c-fr-0008]
    8. Cosmetic composition according to any one of claims 1 to 7, characterized in that the prebiotic and the probiotic, in particular in the form of a pre- / pro-biotic complex, are present in the composition in a total content in active material ranging from 0.05% to 3% by weight of active material relative to the total weight of the composition, preferably from 0.1 to 1% by weight of active material relative to the total weight of the composition.
    [9" id="c-fr-0009]
    9. Cosmetic composition according to any one of claims 1 to 8, characterized in that it is in the form of a care product and / or a makeup product for the skin, the lips or the eyes. , especially for the complexion.
    [10" id="c-fr-0010]
    10. Cosmetic method for caring for and / or making up keratin materials, in particular the skin, lips and / or eyes, comprising at least the application to said keratin materials of a cosmetic care and / or makeup as defined in any one of the preceding claims, in particular a makeup composition for the complexion, the lips or the eyes, preferably for the complexion.
    [11" id="c-fr-0011]
    11. A cosmetic method for caring for and / or making up the skin according to claim 10, intended to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its film. hydrolipidic, improve the integrity and resistance of the skin to stress, in particular to favor its adaptive capacities to the conditions of hypoxia and / or limit the cutaneous consequences of a hypoxic environment, to favor the desquamation and / or the epidermal renewal, to decrease loss of firmness, decrease sagging pores, decrease surface irregularities, improve skin uniformity, promote energetic homeostasis of the skin, and / or promote and / or improve make-up hold and homogeneity its deposit.
    [12" id="c-fr-0012]
    12. Non-therapeutic cosmetic use of at least one cosmetic agent consisting of galactomannans of molar masses of between 5 and 630kDa and crosslinked sulfated galactanes of molar masses of between 7 and 3000kDa, a prebiotic and a probiotic fraction as defined in l 'any one of claims 1 to 7, as an association intended to maintain the cutaneous ecosystem and / or maintain the balance of the cutaneous microbiota, in particular microbial diversity, strengthen the cutaneous barrier and its hydrolipidic film, improve the integrity and the resistance of the skin to stress, in particular promoting its adaptive capacities to hypoxia conditions and / or limiting the cutaneous consequences of a hypoxic environment, favoring desquamation and / or epidermal renewal, reducing the loss of firmness, reducing sagging pores, decrease surface irregularities, improve homo fairness of the complexion, promote energetic homeostasis of the skin, and / or promote and / or improve the hold of the make-up and the uniformity of its deposition.
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    同族专利:
    公开号 | 公开日
    EP3727594A1|2020-10-28|
    EP3727594B1|2022-01-26|
    JP2021508330A|2021-03-04|
    KR20200127981A|2020-11-11|
    US20210137813A1|2021-05-13|
    FR3075622B1|2020-01-17|
    CN111741743A|2020-10-02|
    WO2019122776A1|2019-06-27|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2017063066A1|2015-10-15|2017-04-20|Natura Cosméticos S.A.|Cosmetic composition having probiotic bacteria|
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    FR3047173B1|2016-01-29|2018-02-09|Societe Industrielle Limousine D'application Biologique|COSMETIC AGENT CONSISTING OF GALACTOMANNANES OBTAINED FROM CAESALPINIA SPINOSA AND SULFATE GALACTANES OBTAINED FROM KAPPAPHYCUS ALVAREZII|FR3106495A1|2020-01-29|2021-07-30|Gelyma|Cosmetic composition comprising extracts of Kappaphycus alvarezii for anti-irritation, anti-redness and anti-itching care of the scalp|
    WO2022013897A1|2020-07-15|2022-01-20|O.F.I. Officina Farmaceutica Italiana S.P.A.|Dermatological composition for rebalancing the skin, for increasing its hydration and elasticity and for reducing dynamic disorders|
    CN112704713B|2021-01-07|2022-02-01|中国海洋大学|Kappaphycus cereal powder formula for improving intestinal mucositis caused by chemotherapy|
    法律状态:
    2018-11-26| PLFP| Fee payment|Year of fee payment: 2 |
    2019-06-28| PLSC| Publication of the preliminary search report|Effective date: 20190628 |
    2019-11-20| PLFP| Fee payment|Year of fee payment: 3 |
    2020-11-20| PLFP| Fee payment|Year of fee payment: 4 |
    2021-11-17| PLFP| Fee payment|Year of fee payment: 5 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1763139A|FR3075622B1|2017-12-22|2017-12-22|COSMETIC COMPOSITION COMPRISING AN EXTRACT OF CAESALPINIA SPINOSA, AN EXTRACT OF KAPPAPHYCUS ALVAREZII, AT LEAST ONE PREBIOTIC AND ONE PROBIOTIC.|
    FR1763139|2017-12-22|FR1763139A| FR3075622B1|2017-12-22|2017-12-22|COSMETIC COMPOSITION COMPRISING AN EXTRACT OF CAESALPINIA SPINOSA, AN EXTRACT OF KAPPAPHYCUS ALVAREZII, AT LEAST ONE PREBIOTIC AND ONE PROBIOTIC.|
    US16/956,047| US20210137813A1|2017-12-22|2018-12-21|Cosmetic composition comprising a caesalpinia spinosa extract, a kappaphycus alvarezii extract, at least one prebiotic and a probiotic|
    JP2020534940A| JP2021508330A|2017-12-22|2018-12-21|Cosmetic composition containing Caesarpinia spinosa extract, Kappaficus alberetti extract, at least one prebiotic and probiotic|
    EP18845300.5A| EP3727594B1|2017-12-22|2018-12-21|Cosmetic composition comprising a caesalpinia spinosa extract, a kappaphycus alvarezii extract, at least one prebiotic and a probiotic|
    PCT/FR2018/053502| WO2019122776A1|2017-12-22|2018-12-21|Cosmetic composition comprising a caesalpinia spinosa extract, a kappaphycus alvarezii extract, at least one prebiotic and a probiotic|
    CN201880090041.0A| CN111741743A|2017-12-22|2018-12-21|Cosmetic composition comprising Caesalpinia spinosa extract, Kappaphycus alvarezii extract, at least one prebiotic and a probiotic|
    KR1020207021296A| KR20200127981A|2017-12-22|2018-12-21|A cosmetic composition comprising a Caesalpinia spinosa extract, a capapicus alvarezia extract, at least one prebiotic and a probiotic.|
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